What Is Indigestion?

Indigestion, also referred to as dyspepsia,  is a common term used to describe discomfort or unease in the upper abdomen, often occurring during or after meals.1,2

Common symptoms of indigestion may include:1,2

  • Upper abdominal discomfort or pain
  • Bloating
  • Excessive gas or burping
  • Nausea
  • Feeling full sooner than expected (early satiety)

Causes of Indigestion

Indigestion can arise from more than one underlying cause,1 and understanding what may be driving your symptoms can help you make more informed choices about managing digestive health. Below are some of the most common causes of indigestion.

Indigestion can occur when there is too much stomach acid, or when acid moves to areas where it does not belong. When this happens, acid can irritate the lining of the stomach, oesophagus, or upper intestine, leading to the familiar burning or painful sensations often associated with indigestion.3,4

Excessive stomach acid is commonly linked to conditions such as gastro-oesophageal reflux disease (GERD) or peptic ulcer disease, both of which are recognised causes of chronic indigestion.3,4

Indigestion can also occur when food is not efficiently broken down during digestion. In some people, digestive enzyme activity may be reduced, which is recognised as one of the contributing factors in indigestion.5,6

Digestive enzymes help break down proteins, carbohydrates, and fats so the body can absorb nutrients. When enzyme activity is reduced, food may remain partially digested, contributing to bloating, discomfort after meals, and a feeling that digestion is incomplete.5-7

Everyday habits can also contribute to indigestion. Common triggers may include:8-11

  • Eating heavy meals
  • Eating fatty or spicy foods
  • Drinking soft drinks or alcohol
  • Eating too quickly
  • Psychological stress (e.g. depression)
  • Irregular meal patterns

Stress or depression, in particular, has been shown to influence gut activity and digestive function through the gut-brain axis, which may worsen indigestion symptoms.11

Is Your Indigestion Acid-related or Due to Impaired Digestion?

Although acid-related discomfort and impaired digestion often occur together and share similar symptoms, they are not always driven by the same underlying cause. Addressing symptoms without understanding what may be contributing to them can sometimes provide only temporary relief and may not support long-term digestive balance.

The table below highlights symptoms that may be more commonly associated with acid-related discomfort, impaired digestion, or both.12,13

Symptoms Acid-related Impaired digestion
Early satiety
Pain or burning sensation in chest  
Pain or burning sensation in upper abdomen  
Acid reflux  
Chest pain
Abdominal pain  
Bloating
Unpleasant taste in mouth  
Excessive gas or burping
Symptoms worsen when lying down or bending over

Practical Tips for Indigestion

Simple lifestyle approaches may help support digestion and reduce digestive discomfort. These may include:14,15

  • Eating smaller, more frequent meals
  • Limiting intake of caffeine and alcohol
  • Limiting high-fat and spicy foods
  • Managing stress through relaxation techniques or regular physical activity

When to See a Doctor

While digestive discomfort is common, some symptoms may point to conditions beyond indigestion. You should seek medical advice if you experience:1

  • Persistent or worsening symptoms
  • Unintended weight loss
  • Difficulty swallowing
  • Persistent vomiting

Such symptoms may require further medical evaluation.1

The content here is for information purposes only and does not constitute medical advice. Consult a healthcare professional if symptoms persist or worsen. References:1. Combizym® Prescribing Information (Oct 2021). 2. National Institute of Diabetes and Digestive and Kidney Diseases. Your digestive system and how it works. Available at https://www.niddk.nih.gov/health-information/digestive-diseases/digestive-system-how-it-works. Accessed on 23 January 2026. 3. Tian C, et al. Pancreatic insufficiency. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2025. 4. Ianiro G, et al. Curr Drug Metab. 2016;17(2):187–93. 5. Shandro BM, et al. World J Gastrointest Pharmacol Ther. 2018;9(5):39–46. 6. Garg V, et al. J Int Med Res. 2022;50(3):3000605221086457. 7. Ran ZH, et al. J Dig Dis. 2009;10(1):41–8. 8. Gaviscon® Double Action Mint PL Prescribing Information. Dated September 2018. 9. NICE Guideline. Gastro-oesophageal reflux disease and dyspepsia in adults: investigation and management. Available at www.nice.org.uk/guidance/cg184. Accessed on 6 November 2025. 10. NHS. Antacids. Available at https://www.nhs.uk/medicines/antacids/. Accessed on 6 November 2025. 11. Zantac 360® Prescribing Information. Dated May 2025. 12. Nugent CC, et al. H2 Blockers. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2025. 13. Daba GM, et al. Bioresour Bioprocess. 2021;8(1):52. 14. Shintakuya R, et al. Pancreatology, Vol. 17, Issue 1, 2017 15. Mounsey, A et al. American Family Physician, Vol. 101 No. 2, 2020 16. McNamara D.A., et al. Gastroenterology Clinics of North America, Vol. 29 Issue 4, 2020. 17. Robinson M, et al. Aliment Pharmacol Ther. 2002 Mar;16(3):435-43 18. Digestive Health: What is Digestive Health?, Journal of Nutrition. https://journalofnutrition.org/encyclopedia/what-is-digestive-health/ Accessed 23 April 2026

Rxilient Health

ABOUT US
Rxilient offers full value-chain capabilities, ranging from registration and commercialization to manufacturing and supply chain management. We partner with innovators and multinationals to develop and commercialize market-leading medicines.

Rxilient Health

ABOUT US
Rxilient offers full value-chain capabilities, ranging from registration and commercialization to manufacturing and supply chain management. We partner with innovators and multinationals to develop and commercialize market-leading medicines.


© combizym.com All rights reserved. COM/HKG/DOC/277/2026/rev.01

© combizym.com All rights reserved.COM/HKG/DOC/277/2026/rev.01