When enzyme activity may be insufficient in the body

In some individuals, digestive enzyme activity may be reduced or insufficient, leading to less efficient breakdown of food. This may result in symptoms such as:3,5

Bloating

Abdominal discomfort

Excessive gas

Diarrhoea

Over time, reduced digestive efficiency may affect nutrient absorption, which can influence bone and muscle health, and overall well-being.5

Not all digestive aids work the same way

Many people reach for antacids when digestive discomfort occurs. While antacids can help with acid-related symptoms, they do not address discomfort caused by functional dyspepsia.6,15

Digestive enzyme supplements work differently. Instead of neutralising or reducing stomach acid, they help break down food components, supporting the digestive process itself.1

This distinction matters because indigestion symptoms are not always driven by excess acid. In these cases, digestive enzyme support16—such as Combizym®—can help improve digestive comfort by addressing how food is processed and broken down.

Understanding your digestive aid options

* In a randomised clinical study, symptom remission persisted for more than one week after discontinuing Combizym®.7

Combizym® (Digestive enzymes)

Helps break down proteins, fats, and carbohydrates so food is easier to digest.1,7

Antacids

Neutralises stomach acid to help relieve acid-related discomfort.6,8

Histamine-2 receptor blockers

Reduces the amount of acid produced in the stomach.11,12

Combizym® (Digestive enzymes)

Helps relieve symptoms linked to poor digestion, such as bloating, abdominal discomfort, and belching.1,7

Antacids

Helps relieve symptoms related to acid reflux, such as heartburn and acid regurgitation.6,8

Histamine-2 receptor blockers

Helps relieve acid-related symptoms such as heartburn and sour stomach.11,12

Combizym® (Digestive enzymes)

Provides sustained relief.*7

Antacids

Provides short-term relief (up to 3 hours).9,10,17

Histamine-2 receptor blockers

Provides short-term relief (4–10 hours).12

How Combizym® Supports Digestion

Combizym® tablets feature a dual-layer coating designed to support stable, site-specific release of digestive enzymes as the tablet moves through the digestive system.

Know more

The content here is for information purposes only and does not constitute medical advice. Consult a healthcare professional if symptoms persist or worsen. References:1. Combizym® Prescribing Information (Oct 2021). 2. National Institute of Diabetes and Digestive and Kidney Diseases. Your digestive system and how it works. Available at https://www.niddk.nih.gov/health-information/digestive-diseases/digestive-system-how-it-works. Accessed on 23 January 2026. 3. Tian C, et al. Pancreatic insufficiency. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2025. 4. Ianiro G, et al. Curr Drug Metab. 2016;17(2):187–93. 5. Shandro BM, et al. World J Gastrointest Pharmacol Ther. 2018;9(5):39–46. 6. Garg V, et al. J Int Med Res. 2022;50(3):3000605221086457. 7. Ran ZH, et al. J Dig Dis. 2009;10(1):41–8. 8. Gaviscon® Double Action Mint PL Prescribing Information. Dated September 2018. 9. NICE Guideline. Gastro-oesophageal reflux disease and dyspepsia in adults: investigation and management. Available at www.nice.org.uk/guidance/cg184. Accessed on 6 November 2025. 10. NHS. Antacids. Available at https://www.nhs.uk/medicines/antacids/. Accessed on 6 November 2025. 11. Zantac 360® Prescribing Information. Dated May 2025. 12. Nugent CC, et al. H2 Blockers. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2025. 13. Daba GM, et al. Bioresour Bioprocess. 2021;8(1):52. 14. Shintakuya R, et al. Pancreatology, Vol. 17, Issue 1, 2017 15. Mounsey, A et al. American Family Physician, Vol. 101 No. 2, 2020 16. McNamara D.A., et al. Gastroenterology Clinics of North America, Vol. 29 Issue 4, 2020. 17. Robinson M, et al. Aliment Pharmacol Ther. 2002 Mar;16(3):435-43 18. Digestive Health: What is Digestive Health?, Journal of Nutrition. https://journalofnutrition.org/encyclopedia/what-is-digestive-health/ Accessed 23 April 2026

Rxilient Health

ABOUT US
Rxilient offers full value-chain capabilities, ranging from registration and commercialization to manufacturing and supply chain management. We partner with innovators and multinationals to develop and commercialize market-leading medicines.

Rxilient Health

ABOUT US
Rxilient offers full value-chain capabilities, ranging from registration and commercialization to manufacturing and supply chain management. We partner with innovators and multinationals to develop and commercialize market-leading medicines.


© combizym.com All rights reserved. COM/HKG/DOC/277/2026/rev.01

© combizym.com All rights reserved.COM/HKG/DOC/277/2026/rev.01